Abstract: The spatiotemporal pattern characteristics of cultural heritage distribution mirror the historical human activities within specific geographical areas. Given the current trend towards regionalization in heritage conservation, conducting a comprehensive exploration of this topic is of great significance. Consequently, this article utilizes geospatial analysis methods to investigate the spatiotemporal pattern and its formation mechanism of cultural heritage distribution in Hubei Province. The research reveals that, spatially, the pattern has transformed from a multi-core, point-like distribution into a linear, multi-axis structure. Temporally, the distribution of heritage conservation units (HCUs) has expanded from the hilly and mountainous regions in northern Hubei to the Jianghan Plain and along the Yangtze River, with its evolutionary trajectory closely mirroring the historical development of Hubei. Spatially, it showcases a multi-core clustering pattern and a 'one belt, two axes' spatial configuration. Moreover, the spatiotemporal distribution of HCUs in Hubei is the outcome of the combined influences of natural and human factors, with human factors playing a predominant role and natural factors serving as a foundational support. Additionally, the dominant factors affecting the distribution of HCUs across the four geographical units in Hubei display notable regional variations.